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Updated 2024-11-24 12:32
Norway: Yersinia enterocolitica outbreak reported in five counties
By NewsDesk @infectiousdiseasenews Norway’s Institute of Public Health reports investigating an increased incidence of the gastrointestinal bacterium, Yersinia enterocolitica O3. The infection has been detected in 14 people living in several counties. The patients are between 2 and 57 years old and most are women. The infected are residents of Agder (4), Oslo (4), Rogaland (3), Trøndelag […]The post Norway: Yersinia enterocolitica outbreak reported in five counties appeared first on Outbreak News Today.
Nigeria reports 500 additional COVID-19 cases, Release guidelines to reopen places of worship
By NewsDesk @infectiousdiseasenews Nigerian health authorities reported an additional 501 COVID-19 cases Saturday from 24 states, bringing the country total to 15,682. Eight more fatalities were reported putting the death toll to over 400. Lagos state has recorded the most cases with 7035, about 45 percent of the country total. The Nigeria Centre for Disease Control […]The post Nigeria reports 500 additional COVID-19 cases, Release guidelines to reopen places of worship appeared first on Outbreak News Today.
Recall: Raw Macadamia Nuts, Potential to be contaminated with Salmonella
NOW Health Group, Inc. (NOW), of Bloomingdale, Illinois, is voluntarily recalling its NOW Real Food® Raw Macadamia Nuts – Product Code 7119, Lot#3141055 – because this lot has the potential to be contaminated with Salmonella. This lot was distributed online and in retail stores nationwide. Recalled products include: Item Number Description Lot Number Best By […]The post Recall: Raw Macadamia Nuts, Potential to be contaminated with Salmonella appeared first on Outbreak News Today.
Stenotrophomonas maltophilia: Potential high-risk clones identified in strains in European hospitals
Stenotrophomonas maltophilia are increasingly recognized as significant opportunistic pathogens in healthcare settings worldwide, the global spread of multidrug-resistant strains of this species being the most serious concern. Epidemiological studies are important to identify particular lineages or strains exhibiting clinically relevant phenotypes and to make knowledge-driven healthcare decisions. In this context, researchers from the Bacterial Pathogenesis […]The post Stenotrophomonas maltophilia: Potential high-risk clones identified in strains in European hospitals appeared first on Outbreak News Today.
Malaria cases down in Venezuela in 2020, according to UN data
By NewsDesk @infectiousdiseasenews After seeing a significant rise in malaria in the Bolivarian Republic of Venezuela in recent years, between January and May 2020, the malaria situation in Venezuela, and elsewhere in the Americas is characterized by a reduction in the number of confirmed cases compared to the same period of the previous year. During the […]The post Malaria cases down in Venezuela in 2020, according to UN data appeared first on Outbreak News Today.
Singapore COVID-19: Conditional approval of Remdesivir granted for treatment
By NewsDesk @infectiousdiseasenews Singapore’s Health Sciences Authority (HSA) announced today granting conditional approval for Gilead Sciences Singapore Pte Ltd’s (Gilead) Veklury® (remdesivir). This will allow infectious diseases specialists to administer remdesivir for the treatment of adult patients with COVID-19 infection, who: Have oxygen saturation less than or equal to 94%, or; require supplemental oxygen, or; require […]The post Singapore COVID-19: Conditional approval of Remdesivir granted for treatment appeared first on Outbreak News Today.
Dengue in Singapore: Cases top 10,000, Most cases in first five months since 2013
By NewsDesk @infectiousdiseasenews Singapore health officials reported 870 dengue fever cases last week, a weekly number not seen since the peak years in 2013 and 2014. Through June 9, Singapore reported 10,234 total dengue cases. This is the highest number of cases in the first 5 months of the year since 2013, the largest outbreak year […]The post Dengue in Singapore: Cases top 10,000, Most cases in first five months since 2013 appeared first on Outbreak News Today.
Echinococcus reported in Almaty, Kazakhstan resident
Officials in the Almaty region of Kazakhstan report an unusual case of echinococcosis, a parasitic infection. The patient, a man in his 50s, presented at the emergency department complaining of urinary retention and bursting pains of the abdominal cavity. Surgeons at the City Clinical Hospital No. 4 of Almaty removed four giant cysts with parasites […]The post Echinococcus reported in Almaty, Kazakhstan resident appeared first on Outbreak News Today.
Study aims to determine the number of undetected COVID-19 cases in the United States
A study led by the National Institutes of Health, the University of Alabama at Birmingham and the University of Pittsburgh will examine how many adults in the United States have been infected by the novel coronavirus but did not know they had it. Researchers will analyze blood samples from 10,000 adults to see if they have the […]The post Study aims to determine the number of undetected COVID-19 cases in the United States appeared first on Outbreak News Today.
Ebola outbreak in western DRC grows, Not linked to outbreak in eastern DRC
By NewsDesk @infectiousdiseasenews In a follow-up on a second Ebola Virus Disease (EVD) outbreak in the Équateur Province in the western Democratic Republic of the Congo (DRC) reported on June 1, the World Health Organization (WHO) now reports a total of 12 cases (9 confirmed and 3 probable) with six deaths as of Saturday. This is […]The post Ebola outbreak in western DRC grows, Not linked to outbreak in eastern DRC appeared first on Outbreak News Today.
Combating COVID-19: Biolog-id Joins Forces with LifeShare Blood Center
Biolog-id, LLC, a world leader in connected solutions for blood and other high value health products, announced today that LifeShare Blood Center, a leading provider of blood products in the South Central United States, implemented Biolog-id’s RFID-enabled, data analytics solution in its blood supply chain. The deployed solution provides real-time visibility to convalescent plasma from […]The post Combating COVID-19: Biolog-id Joins Forces with LifeShare Blood Center appeared first on Outbreak News Today.
COVID-19: Europe lockdowns may have prevented 3.1m deaths, according to study
Large-scale lockdowns and other non-pharmaceutical interventions in Europe have been successful in reducing the transmission levels of SARS-CoV-2. This is the conclusion of a modelling study from Imperial College London scientists, published online in Nature Monday, which suggests lockdown measures have been sufficient to control the growth of the epidemic. The team, from the MRC Centre for Global Infectious […]The post COVID-19: Europe lockdowns may have prevented 3.1m deaths, according to study appeared first on Outbreak News Today.
New Zealand COVID-19: No active cases in the country
By NewsDesk @infectiousdiseasenews On Monday, the New Zealand Ministry of Health announced there were no active cases of COVID-19 in the country. The Ministry has been notified by Auckland Regional Public Health that its remaining case has been symptom free for 48 hours and is regarded as recovered. The person has now been released from isolation. […]The post New Zealand COVID-19: No active cases in the country appeared first on Outbreak News Today.
TB drug, rifabutin, active against Acinetobacter baumannii in the lab
USC researchers have discovered that an old antibiotic may be a powerful new tool against a deadly superbug, thanks to an innovative screening method that better mimics conditions inside the human body. The antibiotic, rifabutin, is “highly active” in fighting multidrug-resistant Acinetobacter baumannii, a significant cause of life-threatening infections in medical facilities, researchers found. The […]The post TB drug, rifabutin, active against Acinetobacter baumannii in the lab appeared first on Outbreak News Today.
Brazil records nearly 19K additional COVID-19 cases, Closing in on 700K
By NewsDesk @infectiousdiseasenews The Brazil Ministry of Health recorded 18,912 additional COVID-19 cases and 525 new deaths in the past 24 hours. The country with the second most cases now has 691,758, including 36,455 deaths. Health officials also note that the number of recovered patients totals 283,952 patients and another 371,351 are undergoing medical follow-up. Of […]The post Brazil records nearly 19K additional COVID-19 cases, Closing in on 700K appeared first on Outbreak News Today.
Peru: Coronavirus cases near 200,000, First Indigenous COVID-19 Command in the Loreto
By NewsDesk @infectiousdiseasenews The Peruvian Ministry of Health are reporting 199,696 COVID-19 cases through June 8. Lima continues to be the region with the highest number of COVID-19 infected with 118,036 cases. The following regions also present patients with Covid-19: Callao (14,017), Piura (10,886), Lambayeque (9933), Loreto (6349), La Libertad (5916), Ancash (5443), Ucayali (5421), Arequipa […]The post Peru: Coronavirus cases near 200,000, First Indigenous COVID-19 Command in the Loreto appeared first on Outbreak News Today.
Pediatric Inflammatory Multisystem Syndrome different from Kawasaki disease: Study
A study on children suffering from severe inflammatory symptoms shows the condition is new and distinct from Kawasaki disease. In April, researchers in the UK and several European countries with high numbers of COVID-19 cases recognised a new inflammatory syndrome in children that was similar to Kawasaki disease, a rare syndrome known to affect young […]The post Pediatric Inflammatory Multisystem Syndrome different from Kawasaki disease: Study appeared first on Outbreak News Today.
Chile: COVID-19 cases top 134K, Quarantine for the communes of San Antonio and Calama
By NewsDesk @infectiousdiseasenews The Chile Ministry of Health reported 6,405 new cases of COVID-19 Sunday, of which 5,760 were symptomatic and 645 were asymptomatic. This brings the total cases in the country to 134,150. This an increase of some 100,000 in the past month. Health authorities also reported 96 deaths, bringing the total to 1,637. The […]The post Chile: COVID-19 cases top 134K, Quarantine for the communes of San Antonio and Calama appeared first on Outbreak News Today.
Equine encephalitis vaccine: Bavarian Nordic announces topline results from the the first-in-human trial
Bavarian Nordic A/S announced today topline results from the the first-in-human trial of MVA-BN® WEV, a prophylactic vaccine candidate against three equine encephalitis viruses (western, eastern and Venezuelan), for which there are currently no preventative vaccines available. The Phase 1 trial, funded by the United States Department of Defense’s (DOD) Joint Program Executive Office for Chemical, […]The post Equine encephalitis vaccine: Bavarian Nordic announces topline results from the the first-in-human trial appeared first on Outbreak News Today.
Outbreak News Update: Robert Herriman talks about the brain eating amoeba, Naegleria fowleri
By NewsDesk @infectiousdiseasenews On the recent episode of NEWS TALK with Brandon and Bob, I spend a few moments reminding the public about the swimming risks in warm, fresh water and the brain-eating amoeba, Naegleria fowleri. WATCH my series of interviews at the 2019 Amoeba Summit:The post Outbreak News Update: Robert Herriman talks about the brain eating amoeba, Naegleria fowleri appeared first on Outbreak News Today.
Philippines COVID-19 death toll tops 1,000, More than 200 prisoners infected
By NewsDesk @infectiousdiseasenews Philippines health officials reported an additional nine COVID-19 related fatalities, putting the tally over the 1,000 deaths threshold (1003). The Department of Health also saw 555 additional COVID-19 cases, bringing the country case count to 21,895. The Bureau of Corrections reported that 222 COVID-19 cases have been reported in prisoners, with the New […]The post Philippines COVID-19 death toll tops 1,000, More than 200 prisoners infected appeared first on Outbreak News Today.
Indonesia: Most provinces report less than 10 new COVID-19 cases
By NewsDesk @infectiousdiseasenews Indonesia’s health ministry, aka Kementerian Kesehatan Republik Indonesia, reported an additional 672 COVID-19 cases today, bringing the country total to 31,186, with the following province reporting the most cases–East Java increased 113, South Sulawesi increased 64 cases, Papua 59 cases, and Central Java 51 cases. COVID-19 has spread to all 34 provinces in Indonesia, […]The post Indonesia: Most provinces report less than 10 new COVID-19 cases appeared first on Outbreak News Today.
Cytokine storm: Acalabrutinib assists in calming down in COVID-19 patients in study
The drug acalabrutinib, FDA-approved for the treatment of several types of B cell cancers, improved the oxygenation levels and decreased molecular markers of inflammation in a majority of 19 patients hospitalized for the treatment of severe COVID-19, according to a new study by Mark Roschewski and colleagues. The drug was administered to 11 patients on […]The post Cytokine storm: Acalabrutinib assists in calming down in COVID-19 patients in study appeared first on Outbreak News Today.
False-negative COVID-19 tests: Challenges and implications
As communities across the U.S. have struggled to cope with the effects of the COVID-19 pandemic, many have focused on the lack of widespread testing as a major barrier to safely reopening the country. As progress has been made on this front, concern has shifted to testing accuracy, predominantly with antibody tests, which are designed […]The post False-negative COVID-19 tests: Challenges and implications appeared first on Outbreak News Today.
White-Nose Syndrome reported in dead bats in North Dakota
Little brown bats found dead in western North Dakota died of white-nose syndrome. In early May, the Southwest District Health Unit in Dickinson contacted the North Dakota Game and Fish Department with reports of dead bats found in Medora. Six were submitted to the USGS National Wildlife Health Center in Madison, Wisc. for analysis. The […]The post White-Nose Syndrome reported in dead bats in North Dakota appeared first on Outbreak News Today.
Philippines: Coronavirus cases top 21K, Testing to expand
By NewsDesk @infectiousdiseasenews The Philippines Department of Health reported an additional 714 COVID-19 cases Saturday, bringing the total to 21,340 cases. The new cases account for 350 “fresh” test results or those reported within the last three days and 364 late cases or backlogs validated only recently. Seven additional fatalities were recorded, bringing the total to […]The post Philippines: Coronavirus cases top 21K, Testing to expand appeared first on Outbreak News Today.
Finland COVID-19 cases continue to slow down
By NewsDesk @infectiousdiseasenews The Finnish Institute of Health and Welfare report the coronavirus epidemic has continued to slow down compared to the situation two weeks ago. The weekly average of cases reported to the communicable diseases register has decreased clearly from that reported two weeks ago, but it is about the same as last week. Now […]The post Finland COVID-19 cases continue to slow down appeared first on Outbreak News Today.
Brazil: Dengue cases up 44 percent in the Federal District
By NewsDesk @infectiousdiseasenews Health officials in Brazil have reported 34,456 dengue fever cases through May 23 in the Federal District, an increase of 44 percent compared to 2019 at this time (23,890). The dengue related deaths are at 25, a decrease compared to last year. The undersecretary of Health Surveillance, Eduardo Hage, warns that it is […]The post Brazil: Dengue cases up 44 percent in the Federal District appeared first on Outbreak News Today.
Dengue in Brazil: Cases near 200K in Paraná
By NewsDesk @infectiousdiseasenews The Paraná State Department of Health (Sesa) reported 198,990 confirmed cases of dengue as of June 2, including 139 dengue-related deaths. According to the bulletin, there are cases in 343 municipalities in the state and 237 are in epidemic state of the disease. The bulletin pointed out that of the total cases, 181,298 are […]The post Dengue in Brazil: Cases near 200K in Paraná appeared first on Outbreak News Today.
Antibiotics: Recarbrio gets FDA approval for treatment of HABP/VABP
Merck announced Friday that the U.S. Food and Drug Administration (FDA) has approved a supplemental New Drug Application (sNDA) for RECARBRIO™ (imipenem, cilastatin, and relebactam) for the treatment of patients 18 years of age and older with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by the following susceptible Gram-negative microorganisms: Acinetobacter calcoaceticus-baumannii complex, Enterobacter cloacae, Escherichia […]The post Antibiotics: Recarbrio gets FDA approval for treatment of HABP/VABP appeared first on Outbreak News Today.
Acute Hepatitis A Case in a Food Service Worker in Saco, Maine
By Jory Lange The Maine Center for Disease Control and Prevention (Maine CDC) issued a health advisory after identifying a case of acute hepatitis A virus infection in a Saco, Maine, food service worker. A food service worker infected with Hepatitis A handled food from May 12 to May 23, 2020 at the Sea Salt […]The post Acute Hepatitis A Case in a Food Service Worker in Saco, Maine appeared first on Outbreak News Today.
Australia: Ehrlichiosis infects several dogs in Kimberley region
By NewsDesk @infectiousdiseasenews The Chief Veterinary Officer for the Department of Agriculture, Water and the Environment in Australia, Dr Mark Schipp has reported six cases of the tick-borne illness, Ehrlichiosis in at least six domestic household dogs in Kununurrain the Kimberley region. One dog died from the illness. Government agencies in Australia will undertake further surveillance […]The post Australia: Ehrlichiosis infects several dogs in Kimberley region appeared first on Outbreak News Today.
CDC issues travel notice for dengue in the Americas
By NewsDesk @infectiousdiseasenews The Centers for Disease Control and Prevention (CDC) issued a travel advisory on May 21 for increase of dengue fever in parts of the Americas. Dengue is an ongoing risk in many parts of Central and South America, Mexico, and the Caribbean. Travelers to areas of risk should protect themselves by preventing mosquito […]The post CDC issues travel notice for dengue in the Americas appeared first on Outbreak News Today.
India reports largest daily rise in COVID-19, Delhi hospital beds
By NewsDesk @infectiousdiseasenews India’s Ministry of Health saw 9,887 new COVID-19 cases during the past 24 hours, the largest one day spike so far, bringing the country case tally to more than 237,000 cases. About 115,000 people have recovered and more than 6600 deaths have been recorded. Maharashtra state has recorded the most cases with 80,000, […]The post India reports largest daily rise in COVID-19, Delhi hospital beds appeared first on Outbreak News Today.
Niagara Falls: Health officials attempt to locate two potentially rabid raccoons
Rabies is a zoonotic infection (a disease that spreads from animals to humans) that can cause a rare but life-threatening infection of the brain and nervous system in humans. It usually results from a bite, scratch, or lick from an infected animal. The Niagara County Department of Health reported this week that they are trying […]The post Niagara Falls: Health officials attempt to locate two potentially rabid raccoons appeared first on Outbreak News Today.
Singapore: Dengue cases highest since 2013
By NewsDesk @infectiousdiseasenews In 2013, Singapore reported the largest dengue fever outbreak in recent history recording some 22,318 cases and eight deaths. As of June 4, 2020, the National Environment Agency (NEA) has reported in excess of 9,500 dengue cases, the highest for the same period of the year since 2013, the record year. Since the […]The post Singapore: Dengue cases highest since 2013 appeared first on Outbreak News Today.
Brazil COVID-19 cases top 600K, US sends two million doses of hydroxychloroquine
By NewsDesk @infectiousdiseasenews Brazil’s Health ministry has reported an additional 60,000 COVID-19 cases since June 2,putting the country’s total case count at 614,000. In addition, the death toll has risen to 34,000, surpassing Italy as the country with the third most globally. Earlier this week, the White House announced the United States Government has delivered two […]The post Brazil COVID-19 cases top 600K, US sends two million doses of hydroxychloroquine appeared first on Outbreak News Today.
Texas: Brazos River Authority advises public of brain-eating amoeba as summer nears
By NewsDesk @infectiousdiseasenews Last fall, 10-year-old Lily Mae Avant from Bosque County, Texas contracted the brain-eating amoeba, Naegleria fowleri while swimming in the Brazos River and later died from the infection. Last week, officials with the Brazos River Authority published an advisory about the water-born amoeba that resides in all lakes, streams, rivers and ponds in […]The post Texas: Brazos River Authority advises public of brain-eating amoeba as summer nears appeared first on Outbreak News Today.
COVID-19 tracing: Look for loss of taste and smell, researchers say
King’s College London researchers have called for the immediate use of additional COVID-19 symptoms to detect new cases, reduce infections and save lives. In a letter published in The Lancet, the team discussed how loss of taste and smell – anosmia – should form part of screening measures for the virus. They said: “As countries slowly […]The post COVID-19 tracing: Look for loss of taste and smell, researchers say appeared first on Outbreak News Today.
Researchers urge halt in prescribing hydroxycholoroquine for COVID-19
The sacred oath taken by physicians during graduation from medical school to “First do no harm,” the first words of the Hippocratic Oath, provides a strong impetus for a commentary just published in The American Journal of Medicine. Researchers from Florida Atlantic University’s Schmidt College of Medicine and collaborators from the University of Wisconsin School of […]The post Researchers urge halt in prescribing hydroxycholoroquine for COVID-19 appeared first on Outbreak News Today.
Philippines COVID-19 cases top 20K, Death rate on downward trend
By NewsDesk @infectiousdiseasenews The Philippines Department of Health (DOH) reported 634 COVID-19 cases today, bringing the total to 20,382. Concerning fatal cases of the coronavirus, 10 additional cases were seen, bringing that total to 984. Earlier this week, DOH Undersecretary and Spokesperson Dr. Maria Rosario Singh-Vergeire said that the COVID-19 mortality rate in the Philippines continues […]The post Philippines COVID-19 cases top 20K, Death rate on downward trend appeared first on Outbreak News Today.
Measles in DRC: One of many outbreaks ravaging the country
By NewsDesk @infectiousdiseasenews The Democratic Republic of the Congo (DRC) continues to be in a humanitarian crisis–massive flooding in some areas affecting hundreds of thousands of people and leaving them without clean drinking water, armed clashes and violence in a number of areas around the country and of course, a plethora of infectious disease outbreaks. In […]The post Measles in DRC: One of many outbreaks ravaging the country appeared first on Outbreak News Today.
Dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance
Poison is lethal all on its own — as are arrows — but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even the strongest opponents, from E. coli to MRSA (methicillin resistant Staphylococcus aureus). A team of Princeton researchers reported today in […]The post Dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance appeared first on Outbreak News Today.
Chikungunya vaccine: The Lancet provides a detailed analysis of final Phase 1 results
Valneva SE, a specialty vaccine company, announced today the publication of full data from the Phase 1 clinical trial of its chikungunya vaccine candidate, VLA1553, in the peer-reviewed medical journal The Lancet Infectious Diseases. The Lancet paper provides a detailed analysis of final Phase 1 results and supports the continued clinical development of VLA1553. Wolfgang Bender, Ph.D., M.D., […]The post Chikungunya vaccine: The Lancet provides a detailed analysis of final Phase 1 results appeared first on Outbreak News Today.
COVID-19: Japan approves saliva PCR test
By NewsDesk @infectiousdiseasenews On Tuesday, Japan’s health minister Katsunobu Kato said in a news conference that a saliva-based PCR test for COVID-19 has been approved and is available. “The new test shows high rate of concordance between PCR swab tests of the nose and throat and saliva-based in cases within nine days of the first sign […]The post COVID-19: Japan approves saliva PCR test appeared first on Outbreak News Today.
Salmonella outbreak affects more than 200 in Hong Kong
By NewsDesk @infectiousdiseasenews Hong Kong health officials continue their investigation into a apparent Salmonella outbreak linked to sandwiches. The Centre for Health Protection (CHP) reports identifying a total of 89 clusters of suspected food poisonings affecting 215 persons. Among them, stool specimens of six affected persons and one food remnant sample tested positive for Group D […]The post Salmonella outbreak affects more than 200 in Hong Kong appeared first on Outbreak News Today.
Australia: Hendra virus confirmed in New South Wales horse
By NewsDesk @infectiousdiseasenews Officials in New South Wales (NSW) are reporting the first case of Hendra virus infection in NSW this year in a 17-year-old unvaccinated thoroughbred horse on a property south of Murwillumbah. The owner noticed the horse was depressed and having difficulty breathing on Friday, 29 May. A private veterinarian took samples for Hendra […]The post Australia: Hendra virus confirmed in New South Wales horse appeared first on Outbreak News Today.
Kansas State University: Research team receives $11.3 million COBRE grant to establish infectious disease research center
The National Institutes of Health is awarding a Kansas State University-led team of veterinary researchers with a prestigious five-year, $11.3 million grant under the Centers of Biomedical Research Excellence, or COBRE, program to establish a new Center on Emerging and Zoonotic Infectious Diseases, or CEZID. The center will comprise four primary research projects that will […]The post Kansas State University: Research team receives $11.3 million COBRE grant to establish infectious disease research center appeared first on Outbreak News Today.
Coronavirus chat on NEWS TALK with Brandon and Bob
In this clip from the NEWS TALK with Brandon and Bob show, we discuss a myriad of issues concerning the COVID-19, or coronavirus disease 2019 pandemic like where to get your information, what data is useful and what do we know now that we didn’t know before. Brandon Jones and Robert Herriman give you an […]The post Coronavirus chat on NEWS TALK with Brandon and Bob appeared first on Outbreak News Today.
COVID-19 research: Postoperative death, Pulmonary embolism
COVID-19 patients who undergo surgery are at increased risk of postoperative death Patients undergoing surgery after contracting coronavirus are at greatly increased risk of postoperative death, a new global study published in The Lancet reveals. Researchers found that amongst SARS-CoV-2 infected patients who underwent surgery, mortality rates approach those of the sickest patients admitted to intensive care […]The post COVID-19 research: Postoperative death, Pulmonary embolism appeared first on Outbreak News Today.
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