DailyDirt: Big Bones Are A Myth, But Obesity Has Legit Causes

Some people are naturally skinny and able to eat almost anything they want without gaining weight. Obviously, there are also plenty of folks who need to watch their diets very carefully and exercise regularly to prevent unhealthy weight gain. The causes for obesity are not well understood, and while many observers like to say it's obvious that people need to expend more calories than they consume, the challenge of doing so isn't as simple as it sounds for many. There aren't any miracle diets or drugs, but as we study obesity and understand it more, there could be more palatable treatments someday.

• Mitochondrial genetics could explain metabolic changes with age and with different environmental conditions. Large scale studies of mitochondrial changes in city populations are just beginning, and researchers will try to make sense of how cell genetics influence health. [url]
• A rare chromosomal abnormality can cause Prader-Willi syndrome -- a condition that can be fatal and cruel because its victims can literally eat to death. People with this condition have no sensation of satiety, so they can eat until their stomachs rupture. [url]
• There's evidence to support the idea that intestinal microbes correlate with obesity. A fecal transplant from an overweight daughter to a mother suffering from an intestinal infection resulted in the infection going away -- but also a weight gain problem for the mother that previously didn't exist. [url]

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