People in a study who snorted died toad secretions once became happier for a month

The Colorado River toad (Incilius alvarius) secretes a substance called 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). People in a research study at Maastricht University in the Netherlands "found that inhaling dried-and-powdered toad secretions resulted in increased life satisfaction, better mindfulness, and a decrease in psychopathological symptoms for the duration of the four-week-long study," according to ScienceAlert.

(Image: kuhnmi, CC-BY 2.0)