NFL Week 12 trend plays: Fade the Chargers against rested Bills

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Each week, we highlight the best NFL betting trends and angles to consider as you prepare for the weekend's action. The trends disappointed again in Week 11 with a 1-3 record, though Cleveland's weather certainly didn't help matters.

Here are some notable trends ahead of Week 12.

Chargers at Bills (-6, 53.5), 1 p.m. ET

It's always worth noticing teams that are coming off a bye, and especially when a club is playing the Chargers, who are 1-12 against the spread when facing squads in that spot since 2008. They're also 2-5-1 ATS in their last eight as road underdogs, while the Bills have covered four of their last five as home favorites.

Trend play: Bills -6

Giants (-6, 42.5) at Bengals, 1 p.m.

This line is massive for the Giants, but it's hard to ignore their 17-4 ATS road record since 2018, the league's best over that stretch. The Bengals have generally excelled as underdogs, but they're 1-3-1 ATS in their last five as home 'dogs, and 2-6 ATS in their last eight against NFC teams.

Trend play: Giants -6

Titans at Colts (-3.5, 50.5), 1 p.m.

The Colts embarrassed the Titans in prime time two weeks ago. How might that affect their Week 12 matchup? Teams playing in a revenge spot within two weeks of losing the first contest are a stellar 23-8-1 ATS in the last 32 tries, including 12-2 ATS since 2015. Tennessee is also 5-1 ATS in its last six when attempting to avenge same-season losses.

Trend play: Titans +3.5

Bears at Packers (-9, 45), 8:20 p.m.

As if things aren't already bad enough for the Bears, who have lost four straight with a 1-3 ATS mark, they're in a terrible spot this week against the team's division rivals. The Packers are 18-7 ATS against Chicago since Aaron Rodgers took over at quarterback in 2008, and they're 5-1 ATS in their last six prime-time games.

Trend play: Packers -9

(Odds source: theScore Bet)

C Jackson Cowart is a betting writer for theScore. He's an award-winning journalist with stops at The Charlotte Observer, The San Diego Union-Tribune, The Times Herald-Record, and BetChicago. He's also a proud graduate of UNC-Chapel Hill, and his love of sweet tea is rivaled only by that of a juicy prop bet. Find him on Twitter @CJacksonCowart.

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