How to fix Deathloop ‘stuttering’ issues on PC

Deathloop is the big triple-A game of the moment, and it's an amazing experience - assuming you're not fighting your gaming PC to get it to run smoothly. Bethesda is aware, and a patch seems to be on the way. But as Digital Foundry's Alex Battaglia explains in this in-depth video, there may be a few things you can try right now to fix it, including one weird, counterintuitive trick that instantly made my seemingly stuttery performance smooth.
Also, there's a new patch as of September 21st that Bethesda says might partially fix the issues.
Here's the TL;DR.
- Obvious: Reduce your quality settings
- Also obvious: Try the initial hotfix, now available in Steam
- Counterintuitive: Lock your framerate at 60 or 120fps
Let's start with that...