can nmcli device status but cannot nmcli connection up

Dear all,

Code:
[root@ol76-12102 ~]# nmcli device status
DEVICE TYPE STATE CONNECTION
enp0s10 ethernet connected enp0s10
enp0s9 ethernet connected enp0s9
enp0s16 ethernet connected System enp0s16
enp0s3 ethernet connected enp0s3
enp0s8 ethernet connected enp0s8
virbr0 bridge connected virbr0
lo loopback unmanaged --
virbr0-nic tun unmanaged --https://access.redhat.com/documentat...ith_ifcg_files

Code:[root@ol76-12102 ~]# nmcli connection reloadbut I cannot

Code:
[root@ol76-12102 ~]# nmcli connection up enp0s16
Error: unknown connection 'enp0s16'.I display the interface but cannot up the interface, so how do i up the specified interface in this case enp0s16

many thanks in advance!