Can’t remove /usr/local/bin path in PATH

How to remove /usr/local/bin path in PATH as :

Code:$ cat /etc/profile
# /etc/profile

# Set our umask
umask 022

# Append "$1" to $PATH when not already in.
# This function API is accessible to scripts in /etc/profile.d
append_path () {
case ":$PATH:" in
*:"$1":*)
;;
*)
PATH="${PATH:+$PATH:}$1"
esac
}

# Append our default paths
#append_path '/usr/local/sbin'
#append_path '/usr/local/bin'
append_path '/usr/bin'

# Force PATH to be environment
export PATH

# Load profiles from /etc/profile.d
if test -d /etc/profile.d/; then
for profile in /etc/profile.d/*.sh; do
test -r "$profile" && . "$profile"
done
unset profile
fi

# Unload our profile API functions
unset -f append_path

# Source global bash config, when interactive but not posix or sh mode
if test "$BASH" &&\
test "$PS1" &&\
test -z "$POSIXLY_CORRECT" &&\
test "${0#-}" != sh &&\
test -r /etc/bash.bashrc
then
. /etc/bash.bashrc
fi

# Termcap is outdated, old, and crusty, kill it.
unset TERMCAP

# Man is much better than us at figuring this out
unset MANPATH

$ echo $PATH
/usr/local/bin:/usr/bin:/bin:/usr/bin/site_perl:/usr/bin/vendor_perlCan't work
Please help out, thanks before