Lab-Grown Brain Cells Play Video Game Pong

An anonymous reader quotes a report from the BBC: Researchers have grown brain cells in a lab that have learned to play the 1970s tennis-like video game, Pong. They say their "mini-brain" can sense and respond to its environment. Writing in the journal Neuron, Dr Brett Kagan, of the company Cortical Labs, claims to have created the first ''sentient'' lab-grown brain in a dish. Other experts describe the work as ''exciting'' but say calling the brain cells sentient is going too far. "We could find no better term to describe the device,'' Dr Kagan says. ''It is able to take in information from an external source, process it and then respond to it in real time." The research team: grew human brain cells grown from stem cells and some from mouse embryos to a collection of 800,000; connected this mini-brain to the video game via electrodes revealing which side the ball was on and how far from the paddle. In response, the cells produced electrical activity of their own. They expended less energy as the game continued. But when the ball passed a paddle and the game restarted with the ball at a random point, they expended more recalibrating to a new unpredictable situation. The mini-brain learned to play in five minutes. It often missed the ball -- but its success rate was well above random chance. Although, with no consciousness, it does not know it is playing Pong in the way a human player would, the researchers stress. Dr Kagan hopes the technology might eventually be used to test treatments for neurodegenerative diseases such as Alzheimer's. "When people look at tissues in a dish, at the moment they are seeing if there is activity or no activity. But the purpose of brain cells is to process information in real time," he says. "Tapping into their true function unlocks so many more research areas that can be explored in a comprehensive way." Next, Dr Kagan plans to test the impact alcohol has on the mini-brain's ability to play Pong. If it reacts in a similar way to a human brain, this would underscore just how effective the system might be as an experimental stand-in. As the "mini-brains" become more complex, Dr Kagan's team says they'll be working with bioethicists to ensure they do not accidentally create a conscious brain. "We have to see this new technology very much like the nascent computer industry, when the first transistors were janky prototypes, not very reliable -- but after years of dedicated research, they led to huge technological marvels across the world," he says.

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