Advances in Eye Scans and Protein Structure Win 2023 Lasker Awards

The prestigious Lasker Awards were given this week to scientists making advances in the diagnosis of eye disease, the prediction of cellular protein structure and the intricacies of the immune system. The awards, closely watched by researchers in biomedical fields, often foreshadow Nobel Prizes. The New York Times adds: The Lasker-DeBakey Clinical Medical Research Award was given to a team of three scientists, led by James G. Fujimoto, a professor of electrical engineering at the Massachusetts Institute of Technology, who helped invent optical coherence tomography. The technology can detect conditions like macular degeneration and diabetic retinopathy earlier than previous methods, preventing blindness. O.C.T. now is commonly used in ophthalmology offices, where the patient simply rests a chin and forehead against an instrument for a brief scan. The method, invented in 1991, offers a staggering amount of detail about the retina, a layer of tissue at the back of the eye critical to vision. "It's not much thicker than a strand of hair, but it has 10 internal layers," said Dr. David Huang, an ophthalmologist at the Casey Eye Institute at Oregon Health & Science University who helped to invent the method. Before O.C.T., an ophthalmologist could dilate a patient's eyes with eye drops to enlarge the pupil, and then use a magnifying lens and special light to examine the retina. An O.C.T. scan "can measure the thickness of the retina, the fluid pockets in it and the abnormal blood vessel growth," detecting small lesions that have not yet caused symptoms, Dr. Huang added.

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