Google DeepMind's 'Leap Forward' in AI Could Unlock Secrets of Biology

Researchers have hailed another "leap forward" for AI after Google DeepMind unveiled the latest version of its AlphaFold program, which can predict how proteins behave in the complex symphony of life. From a report: The breakthrough promises to shed fresh light on the biological machinery that underpins living organisms and drive breakthroughs in fields from antibiotics and cancer therapy to new materials and resilient crops. "It's a big milestone for us," said Demis Hassabis, the chief executive of Google DeepMind and the spin-off, Isomorphic Labs, which co-developed AlphaFold3. "Biology is a dynamic system and you have to understand how properties of biology emerge through the interactions between different molecules." Earlier versions of AlphaFold focused on predicting the 3D structures of 200m proteins, the building blocks of life, from their chemical constituents. Knowing what shape a protein takes is crucial because it determines how the protein will function -- or malfunction -- inside a living organism. AlphaFold3 was trained on a global database of 3D molecular structures and goes a step further by predicting how proteins will interact with the other molecules and ions they encounter. When asked to make a prediction, the program starts with a cloud of atoms and steadily reshapes it into the most accurate predicted structure. Writing in Nature, the researchers describe how AlphaFold3 can predict how proteins interact with other proteins, ions, strands of genetic code, and smaller molecules, such as those developed for medicines. In tests, the program's accuracy varied from 62% to 76%.

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