DNA-Based Bacterial Parasite Uses Completely New DNA-Editing Method

Scientists have uncovered a new gene-editing tool with potential to rival CRISPR, according to studies published in Nature on Wednesday. The system, based on a bacterial DNA parasite called IS110, uses RNA guides to target specific genomic locations. While showing promise for precise DNA cutting, the method currently lacks the accuracy needed for human applications. At best, it achieved 94% accuracy in lab tests. The team also revealed the molecular structure of IS110's DNA-cutting enzyme, shedding light on its unique four-step editing mechanism. Nature, 2024. DOI: 10.1038/s41586-024-07552-4, 10.1038/s41586-024-07570-2.

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