Akira Endo obituary

Japanese biochemist whose work on fungal extracts led to the creation of the first statin

The Japanese biochemist Akira Endo, who has died aged 90, was the creator of the first statin, a drug that lowers low-density lipoprotein (LDL) cholesterol, through his pioneering work with fungal extracts. Endo believed - and eventually proved - that fungi could yield a substance to block cholesterol production.

Known as bad" cholesterol, LDL cholesterol narrows the arteries, raising the likelihood of a heart attack or stroke. First licensed in 1987, statins were a game-changer in the treatment of heart disease. Today, approximately 200 million people take them daily and they are the most commonly prescribed drugs in the UK.