Air Pollution Can Decrease Odds of Live Birth After IVF By 38%, Study Finds

An anonymous reader quotes a report from The Guardian: Air pollution exposure can significantly decrease the chance of a live birth after IVF treatment, according to research that deepens concern about the health impacts of toxic air on fertility. Pollutant exposure has previously been linked to increased miscarriage rates and preterm births, and microscopic soot particles have been shown to travel through the bloodstream into the ovaries and the placenta. The latest work suggests that the impact of pollution begins before conception by disrupting the development of eggs. "We observed that the odds of having a baby after a frozen embryo transfer were more than a third lower for women who were exposed to the highest levels of particulate matter air pollution prior to egg collection, compared with those exposed to the lowest levels," said Dr Sebastian Leathersich, a fertility specialist and gynaecologist from Perth who is due to present the findings on Monday at the European Society of Human Reproduction and Embryology annual meeting in Amsterdam. [...] The study analyzed fertility treatments in Perth over an eight-year period, including 3,659 frozen embryo transfers from 1,836 patients, and tracked whether outcomes were linked to the levels of fine particulate matter, known as PM10. The overall live birthrate was about 28% per transfer. However, the success rates varied in line with exposure to pollutants in the two weeks leading up to egg collection. The odds of a live birth decreased by 38% when comparing the highest quartile of exposure to the lowest quartile. "These findings suggest that pollution negatively affects the quality of the eggs, not just the early stages of pregnancy, which is a distinction that has not been previously reported," Leathersich said. The team now plan to study cells directly to understand why pollutants have a negative effect. Previous work has shown that the microscopic particles can damage DNA and cause inflammation in tissues. The report notes that the link between air pollution and live birth "was apparent despite excellent overall air quality during the study period, with PM10 and PM2.5 levels exceeding WHO guidelines on just 0.4% and 4.5% of the study days." It adds: "Australia is one of just seven countries that met the WHO's guidelines in 2023, and this study is the latest to show evidence of harm even at relatively low levels of pollution." The study has been published in the journal Human Reproduction.

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