2025 NFL Week 4 odds, betting: Full list of Week 4 spreads

The 2025-26 NFL regular season has begun and Week 3 saw a few huge upsets (Browns beating the Packers outright as 7.5-point home underdogs and Panthers winning 30-0 over Falcons as 4.5-point home 'dogs), along with the Kansas City Chiefs finally getting their first win.

It's never too early to look ahead to next week, though, and sportsbooks have already posted lines for every matchup - including a showdown between Patrick Mahomes and Lamar Jackson in Kansas City.

Here are the odds for every Week 4 NFL game at BetMGM:

Thursday, Sept. 25

Seattle Seahawks at Arizona Cardinals (-1.5, 43.5)

Sunday, Sept. 28

9:30 a.m. ET

Minnesota Vikings (-1.5, 41.5) at Pittsburgh Steelers (in Dublin, Ireland)

1 p.m. ET

Tennessee Titans at Houston Texans (-7, 39.5)

Washington Commanders (-2.5, 45.5) at Atlanta Falcons

New Orleans Saints at Buffalo Bills (-16.5, 47.5)

Cleveland Browns at Detroit Lions (-8.5, 45.5)

Carolina Panthers at New England Patriots (-4.5, 44.5)

Los Angeles Chargers (-5.5, 44.5) at New York Giants

Philadelphia Eagles (-3, 45.5) at Tampa Bay Buccaneers

4 p.m. ET

Indianapolis Colts at Los Angeles Rams (-3.5, 47.5)

Jacksonville Jaguars at San Francisco 49ers (-4, 45.5)

Baltimore Ravens at Kansas City Chiefs (-2.5, 48.5)

Chicago Bears at Las Vegas Raiders (-1.5, 47.5)

Sunday Night Football

Green Bay Packers (-6.5, 48.5) at Dallas Cowboys

Monday, Sept. 29

New York Jets at Miami Dolphins (-2.5, 44.5)

Cincinnati Bengals at Denver Broncos (-7.5, 45.5)