2025 NFL Week 5 odds, betting: Full list of Week 5 spreads

The 2025-26 NFL regular season in in full swing, and Week 4 saw a few interesting results (New York Giants beating the Los Angeles Chargers outright as 6.5-point home underdogs and Cowboys-Packers playing to a 40-40 tie), along with the Kansas City Chiefs looking like their old selves in a dominant 37-20 win over the Baltimore Ravens as 2.5-point underdogs.

It's never too early to look ahead to next week, though, and sportsbooks have already posted lines for every matchup.

Here are the odds for every Week 5 NFL game at BetMGM:

Thursday

San Francisco 49ers at Los Angeles Rams (-3.5, 47)

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Sunday

9:30 a.m. ET

Minnesota Vikings (-3.5, 36.5) at Cleveland Browns in London

1 p.m. ET

Las Vegas Raiders at Indianapolis Colts (-6.5, 48)

New York Giants (-1.5, 41.5) at New Orleans Saints

Dallas Cowboys (-2.5, 47.5) at New York Jets

Denver Broncos at Philadelphia Eagles (-4.5, 43.5)

Miami Dolphins (-1.5, 45.5) at Carolina Panthers

Houston Texans at Baltimore Ravens (-6.5, 43.5)

4 p.m. ET

Tennessee Titans at Arizona Cardinals (-9.5, 41.5)

Tampa Bay Buccaneers at Seattle Seahawks (-3, 44.5)

Detroit Lions (-8.5, 49.5) at Cincinnati Bengals

Washington Commanders at Los Angeles Chargers (-2.5, 47.5)

Sunday Night Football

New England Patriots at Buffalo Bills (-8.5, 50.5)

Monday

Kansas City Chiefs (-3, 45.5) at Jacksonville Jaguars

Bye-week teams: Falcons, Bears, Packers, Steelers