Eagles vs. 49ers NFL playoffs wild-card betting odds, picks and predictions: Best bets for Eagles-49ers

The NFC East champion Philadelphia Eagles will host the San Francisco 49ers on Sunday in a rematch of the NFC championship game from a few seasons ago. The 49ers had a chance to win the NFC's No. 1 seed, but lost 13-3 to the Seattle Seahawks in Week 18 and fell to No. 6 instead.

Here is insight from oddsmakers for the game and our team of NFL handicappers provides its favorite wagers on the game.

Odds courtesy of BetMGM.

No. 6 San Francisco 49ers at No. 3 Philadelphia Eagles (-5, 44.5)

What oddsmakers are saying

"As expected, all Eagles money here. We opened -3, up to Philadelphia -5. While the injuries continue to plague the 49ers and the defense leaves something to be desired, I can't remember the last time the Eagles played four great quarters on offense. Total has dropped from 46.5 down to 44.5." - Thomas Gable, sportsbook director at The Borgata

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"This is the game where we've seen some sharp action on Eagles. We opened at -3.5, up to -5.5, total has moved down from 46.5 down to 44.5. For the 49ers, this might be the time where the wheels fall off. They played an easy schedule, but there are so many injuries on defense. Brock Purdy & Co. have been able to outscore lesser teams, but they also got beat up in the Seahawks game." - Joey Feazel, head of NFL trading at Caesars Sportsbook

Best bets

Matt Russell: It's been five games since Jalen Hurts scored a rushing touchdown, but it's been longer than that since the Eagles found themselves in a must-win game. So, while the odds for Hurts to score have crept up as his rushing activity has dipped down, it's go-time for the fresh-legged Eagles, who took last week off for the sole purpose of having all hands on deck for the playoffs.

What that should mean is Hurts' legs are also on deck, and the page of the playbook that says tush push" should be open again. That was the case when Hurts scored 14 times last season, plus five more times in the playoffs. The Eagles turned his legs off after eight rushing touchdowns in the first two-thirds of the season, but at plus-money instead of his usual odds-on listing, let's take a shot with Hurts to get back into the end zone now that the games are important to Philly again.

Bet: Jalen Hurts anytime TD (+125)

Michael Fiddle: Spotting sharp action is a principle part of my NFL betting approach. The NFL market is remarkably efficient, which means digesting the line moves and understanding direction throughout the week is a significant value add when placing bets.

In this game, the Eagles and the under have clearly been bet, as the odds have moved from Eagles -3 to -5.5 and the total has dropped from 46.5 to 44.5. When a number moves off the 3, it becomes hard to chase the favorite at a bigger number. However, the key numbers chart still signals a viable bet on the game total.

Over the last three NFL seasons, 43 and 44 are both among the most common NFL scoring outcomes. On the other end, the move from 46.5 down to 44.5 means the number moved through 45 and 46, neither of which are key numbers or inside the top 15 most common NFL scoring outcomes. From a football perspective, both of these teams are run-heavy teams and will lean on their superstar running backs in Saquon Barkley and Christian McCaffrey.

In an outdoor playoff environment, the best bet on this game is the under.

Bet: Under 44.5