49ers 2026 NFL Draft: Picks by round, biggest needs, best fits

The 2026 NFL Draft kicks off live from Pittsburgh on Thursday, April 23 and the latest crop of rookies will be hearing their names called all weekend long. For the San Francisco 49ers, the biggest need is an obvious one: Interior offensive line.

The 49ers need more depth and competition across their entire offensive line. San Francisco lost starting guard Spencer Burford in free agency, and standout left tackle Trent Williams will be 38 years old at the start of the season.

MORE: Biggest need for every team entering 2026 NFL Draft

Here's everything you need to know about the San Francisco 49ers for this year's draft, including a round-by-round look at picks and a potential trade candidate already on the roster.

San Francisco 49ers NFL Draft best prospect fit: TE Eli Stowers, Vanderbilt

Per USA TODAY's Ayrton Ostly:

San Francisco has immediate needs on the offensive line but this one would be too much fun to pass up. Stowers is second only to Sadiq as an outlier athlete at the tight end position in this class. The 49ers lack a reliable field stretcher, and Kyle Shanahan is creative enough to get it done with a tight end in performing that role. His inconsistent blocking would be less of a concern with Luke Farrell and Jake Tonges already on the roster.

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San Francisco 49ers NFL Draft trade candidate: WR Brandon Aiyuk

Per USA TODAY's Jack McKessy:

San Francisco head coach Kyle Shanahan said at the league meetings that the team is still hoping to trade Aiyuk this offseason. While it seems clear that Aiyuk's time with the 49ers is up, the 28-year-old receiver still could have a No. 1 wide receiver ceiling and a floor as a strong No. 2 receiver. Perhaps the draft will provide the catalyst the 49ers need to move the disgruntled veteran in return for some draft capital.

MORE: One player for all 32 teams who could be traded during the NFL draft

San Francisco 49ers NFL Draft Picks by round

Round 1

• No. 27 (1.27)

Round 2

• No. 58 (2.26)

Round 3

• None

Round 4

• No. 127 (4.27)
• No. 133 (4.33) Compensatory pick
• No. 138 (4.38) Compensatory pick
• No. 139 (4.39) Compensatory pick

Round 5

• None

Round 6

• None

Round 7

• None

This article originally appeared on USA TODAY: San Francisco 49ers 2026 NFL Draft: Picks, team needs, trade candidates