NFL Week 1 Odds & Betting Lines: Super Bowl Rematch Kicks Off Season
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Football will be back before you know it.
The 2026 NFL season opens on Wednesday, September 9, with the defending champion Seattle Seahawks reportedly hosting a Super Bowl rematch against the New England Patriots, marking the first season opener to feature such stakes.
Australia will also dip its toe into the pigskin as an NFC West battle between the San Francisco 49ers and Los Angeles Rams takes place at the Melbourne Cricket Ground on Friday, September 11.
Once the full schedule is announced on Thursday, we'll provide complete coverage of the latestNFL Week 1 odds, betting lines, spreads, and matchup analysis for every game of the opening weekend.
NFL Week 1 Odds| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Patriots vs Seahawks | TBD | TBD | TBD |
49ers |  +2.5-102 -2.5 -118 | +124-148 | o48.5 -110 u48.5 -110 |
Cowboys |  -1.5 -115 +1.5 -105 | -130+110 | o47.5 -110 u47.5 -110 |
Broncos |  +2.5 -115 -2.5-105 | +130-155 | o42.5 -110 u42.5 -110 |
Odds as of 5-13-2026.Odds from DraftKings, one of ourbest betting apps. Sign up with ourDraftKingspromo code, or get one of our othersportsbook promos.
Primetime ProwessThe John Harbaugh era in Gotham begins on Sunday Night Football when the New York Giants host the Dallas Cowboys.
Meanwhile, the Kansas City Chiefs are set to play host to the Denver Broncos on Monday, September 14, potentially marking the return of Patrick Mahomes.
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