2026 NFL Odds Week 1: Lines, Spreads, Results For All 16 Games

Headlined by a Sept. 9 Super Bowl rematch between the Seahawks and Patriots, as well as the NFL's first-ever game in Australia between the Rams and 49ers, Week 1 is absolutely loaded. Here are the lines for every Week 1 matchup at bet365 Sportsbook as of Sept. 11. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Patriots 10, Seahawks 13 Spread:Seahawks -3.5 (NE covers)O/U: 44.5 (Under hits) 49ers 27, Rams 7 Spread:Rams -3.5 (SF covers)O/U: 48.5 (Under hits) Falcons @ Steelers Spread:Steelers -5.5Moneyline:Steelers -245, Falcons +200O/U: 41.5 Ravens @ Colts Spread:Ravens -3.5Moneyline:Ravens -180, Colts +150O/U: 47.5 Bills @ Texans Spread:Bills -1.5Moneyline:Bills -120, Texans +100O/U: 44.5 Bears @ Panthers Spread:Bears -3.5Moneyline:Bears -170, Panthers +145O/U: 47.5 Browns @ Jaguars Spread:Jaguars -8.5Moneyline:Jaguars -425, Browns +325O/U: 40.5 Saints @ Lions Spread:Lions -6.5Moneyline:Lions -330, Saints +265O/U: 49.5 Jets @ Titans Spread:Titans -1.5Moneyline:Titans -120, Jets +100O/U: 38.5 Buccaneers @ Bengals Spread:Bengals -3.5Moneyline:Bengals -200, Buccaneers +165O/U: 50.5 Cardinals @ Chargers Spread:Chargers -9.5Moneyline:Chargers -500, Cardinals +375O/U: 47.5 Packers @ Vikings Spread:Vikings -1.5Moneyline:Vikings -125, Packers +105O/U: 46.5 Dolphins @ Raiders Spread:Raiders -3.5Moneyline:Raiders -170, Dolphins +145O/U: 40.5 Commanders @ Eagles Spread:Eagles -5.5Moneyline:Eagles -240, Commanders +195O/U: 44.5 Cowboys @ Giants Spread:Cowboys -2.5Moneyline:Cowboys -160, Giants +135O/U: 48.5 Broncos @ Chiefs Spread:Chiefs -2.5Moneyline:Chiefs -150, Broncos +125O/U: 43.5