Chargers vs. Cardinals Injury Report: R.J. Mickens, Khalil Mack full participants

INGLEWOOD, CALIFORNIA - DECEMBER 8: RJ Mickens #27 of the Los Angeles Chargers warms up prior to the game against the Philadelphia Eagles at SoFi Stadium on December 8, 2025 in Inglewood, California. (Photo by Brooke Sutton/Getty Images) | Getty Images

The Chargers got a little bit healthier on their second injury report of Week One.

Veteran edge rusher Khalil Mack returned from his rest day and was a full participant. Second-year safety R.J. Mickens improved from a limited participant to full on Thursday. That leaves the Chargers now with a fully healthy safety group.

Cornerback Deane Leonard was once again a DNP for the second consecutive day. If he ends up missing this week's game, the Chargers will be without one of their top special teams players and it's likely second-year corner Nikko Reed will be one of their game day elevations.

thursday's injury report for week 1 vs AZ pic.twitter.com/JQuQW3Cb7J

- Los Angeles Chargers (@chargers) September 10, 2026

Running back Keaton Mitchell, wide receiver Brenen Thompson, and edge rusher Tuli Tuipulotu were all listed as limited participants once again. If I had to guess, all three will be good to go come Sunday, but right now the team is choosing to take a cautious approach ahead of the regular season opener.