Chargers-Bills Injury Report: Brenen Thompson, Kayode Awosika OUT for Week 3

INGLEWOOD, CA - SEPTEMBER 13: Brenen Thompson #89 of the Los Angeles Chargers during warmups prior to an NFL game between the Arizona Cardinals and the Los Angeles Chargers on September 13, 2026, at SoFi Stadium in Inglewood, California. (Photo by Greg Fiore/Icon Sportswire via Getty Images) | Icon Sportswire via Getty Images

The Chargers will be without a handful of starters this week as they travel to face the Bills in Buffalo.

Six players were ruled out on Friday, most of which were expected given comments from Jim Harbaugh earlier in the week. Offensive guard Kayode Awosika and defensive tackle Dalvin Tomlinson, both of whom were injured and left the game against the Raiders, are out this week. Safety Elijah Molden and offensive lineman Trey Pipkins are also set to miss their second consecutive game.

Tight end Charlie Kolar will also sit out this week after undergoing surgery on his forearm.

game status for week 3 at BUF

QUESTIONABLE - Rodney Shelley, Trey Lance

OUT - Kayode Awosika, Charlie Kolar, Elijah Molden, Trey Pipkins, Brenen Thompson, Dalvin Tomlinson

- Los Angeles Chargers (@chargers) September 25, 2026

Cornerback Rodney Shelley, who allowed a touchdown in two snaps played against the Raiders, is questionable to play on Sunday. Backup quarterback Trey Lance also popped up on the injury report with a groin injury. If that situation somehow gets worse, third-stringer D.J. Uiagalelei may end up being active on game day, not just as the emergency quarterback.