Make your Week 10 NFL picks

INGLEWOOD, CALIFORNIA - OCTOBER 18: Puka Nacua #12 of the Los Angeles Rams and head coach Mike LaFleur of the Arizona Cardinals hug after Arizona's 18-16 win at SoFi Stadium on October 18, 2026 in Inglewood, California. (Photo by Harry How/Getty Images) | Getty Images

Week 10 begins the second half of the NFL regular season. With the playoff picture beginning to take shape in both conferences, every matchup carries added importance as teams look to leapfrog one another in the standings.

There are plenty of intriguing matchups, potential upsets, and opportunities for teams to make statements this weekend. With 7 divisional battles, Week 10 features several games that could go either way. Which teams will come through, and which teams are starting to fade? Let's break down every matchup and make our Week 10 NFL picks.

Make your own Week 10 picks?CLICK HEREMy Week 10 Picks

(Bye: Chicago Bears, Denver Broncos, Philadelphia Eagles, Tampa Bay Buccaneers)

Washington Commanders @ New York Giants - Thurs., 8:15 p.m. ET

Jayden Daniels simply does not have enough of a supporting cast in 2026 to be competitive. The Commanders defense will get better with the presence of Sonny Styles.

The only reason this game will be close is because the Giants are working with JJ McCarthy / Jameis Winston at quarterback.

My Pick: Giants 26-20

New England Patriots @ Detroit Lions - Sun., 9:30 a.m. ET (Munich)

The Patriots were embarrassed by the Packers. Jared Goff will not have the same type of field day but Jahmyr Gibbs will be the focal point that gets the Lions the win.

My Pick: Lions 24-20

Buffalo Bills @ New York Jets - Sun., 1:00 p.m. ET

I don't think I will ever pick the Jets to win a game.

My Pick: Bills 38-17

Carolina Panthers @ New Orleans Saints - Sun., 1:00 p.m. ET

The NFC South plays itself. The Panthers are the more complete team but traveling to New Orleans could present challenges.

My Pick: Panthers 31-28 (OT)

Houston Texans @ Cleveland Browns - Sun., 1:00 p.m. ET

The Texans will start their second half ascension to threaten the Patriots for the AFC's 7th seed.

My Pick: Texans 24-13

Jacksonville Jaguars @ Tennessee Titans - Sun., 1:00 p.m. ET

I hope the Jaguars represent the AFC this year. They made some splash moves and they have a great opportunity to earn the #1 seed with a weak AFC South.

My Pick: Jaguars 33-14

Kansas City Chiefs @ Atlanta Falcons - Sun., 1:00 p.m. ET

I could see this being a trap game for the Chiefs who have to slow down Bijan Robinson. Meanwhile, the Falcons must win with a 3-6 record and being 4th in the division.

My Pick: Falcons 24-20

Miami Dolphins @ Indianapolis Colts - Sun., 1:00 p.m. ET

Jeff Hafley might be starting to get more out of the defense in Miami after holding the Patriots to 24 points and the Lions to 19 points. The Colts have made it known that they are punting on the 2026 season.

My Pick: Dolphins 28-25

Minnesota Vikings @ Green Bay Packers - Sun., 1:00 p.m. ET

Even though the Vikings have Kirk Cousins in place to help the offense, I think the Packers defense is playing good football. Not to mention that their passing offense is the best in football right now.

My Pick: Packers 27-18

Seattle Seahawks @ Las Vegas Raiders @ Sun., 4:05 p.m. ET

Klint Kubiak gets to face off against this former team with rookie quarterback - Fernando Mendoza. Mike Macdonald will make it a point of emphasis to rattle the rookie signal caller. I'm willing to bet he throws 3 interceptions in this one or takes 5+ sacks.

My Pick: Seahawks 24-6

Los Angeles Rams @ Arizona Cardinals - Sun., 4:05 p.m. ET

The Rams need this game to get a divisional win (improving divisional record) and move themselves to 4-2 in NFC games. Doing so, would put more pressure on Minnesota, Green Bay, and Seattle.

My Pick: Rams 23-9

San Francisco 49ers @ Dallas Cowboys - Sun., 4:25 p.m. ET

Dallas's defense is about to get worked.

My Pick: 49ers 37-27

Pittsburgh Steelers @ Cincinnati Bengals - Sun., 8:20 p.m. ET

A pretty good Sunday Night Football game on tap. Aaron Rodgers travels to Joe Burrow and the Bengals with first place in the AFC North on the line. The Bengals get this one since its a home game.

My Pick: Bengals

Los Angeles Chargers @ Baltimore Ravens - Mon., 8:15 p.m. ET

The Jesse Minter game. Jacoby Brissett tries to lead a win over the winless Chargers. Minter should know how to attack Justin Herbert.

My Pick: Ravens 20-17