Article 4G8H8 Huntington’s disease: Searching for the origins of the depressive symptoms

Huntington’s disease: Searching for the origins of the depressive symptoms

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About 40% of the affected patients with Huntington's disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase -an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington's disease, ["]

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