Is installing an OS on USB 3.0 more difficult with some partitioning software?

I generally prefer gparted and its GUI for partitioning, as its simple and I've been using it a long time. This build is running on a 128G USB stick, Mate 20.

I have one other USB 3.0 stick, and I have been having a dickens of a time with the installer for several Distros. In theory, isn't the USB exactly the same as installing to an SDD/HDD? Has anyone else a scenario where the same install (& its partitioning software) would work on a hard drive but not a USB?