Scientists Seek To Solve Mystery of Why Some People Do Not Catch Covid

Most people know someone who has stubbornly resisted catching Covid, despite everyone around them falling sick. Precisely how they do this remains a mystery, but scientists arebeginning to find some clues. From a report: The hope is that identifying these mechanisms could lead to the development of drugs that not only protect people from catching Covid, but also prevent them from passing it on. Phoebe Garrett is not the only challenge trial participant to have avoided becoming infected. Of the 34 who were exposed to the virus, 16 failed to develop an infection (defined as two consecutive positive PCR tests) -- although around half of them transiently tested positive for low levels of the virus, often several days after exposure. Possibly, this was a reflection of the immune system rapidly shutting down an embryonic infection. "In our previous studies with other viruses, we have seen early immune responses in the nose that are associated with resisting infection," said Prof Christopher Chiu at Imperial College London, who led the study. "Together, these findings imply that there is a struggle between the virus and host, which in our 'uninfected' participants results in prevention of infection taking off." Some of them also reported some mild symptoms, such as a stuffy nose, sore throat, tiredness, or headache -- although, since these commonly occur in everyday life, they may have been unrelated to virus exposure.

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