Long-Dormant Viruses Are Now Waking Up After 50,000 Years as Planet Warms

This week Bloomberg explored so-called "zombie viruses" - that is, long-dormant microbes which they call "yet another risk that climate change poses to public health" as ground that's been frozen for "milleniums" suddenly starts thawing - for example, in the Arctic, which they write is warming "faster than any other area on earth."With the planet already 1.2C warmer than pre-industrial times, scientists are predicting the Arctic could be ice-free in summers by 2030s. Concerns that the hotter climate will release trapped greenhouse gases like methane into the atmosphere as the region's permafrost melts have been well-documented, but dormant pathogens are a lesser explored danger. Last year, virologist Jean-Michel Claverie's team published research showing they'd extracted multiple ancient viruses from the Siberian permafrost, all of which remained infectious... Ways in which this could present a threat are still emerging. A heat wave in Siberia in the summer of 2016 activated anthrax spores, leading to dozens of infections, killing a child and thousands of reindeer. In July this year, a separate team of scientists published findings showing that even multicellular organisms could survive permafrost conditions in an inactive metabolic state, called cryptobiosis. They successfully reanimated a 46,000-year-old roundworm from the Siberian permafrost, just by re-hydrating it... Claverie first showed "live" viruses could be extracted from the Siberian permafrost and successfully revived in 2014. For safety reasons his research focused only on viruses capable of infecting amoebas, which are far enough removed from the human species to avoid any risk of inadvertent contamination. But he felt the scale of the public health threat the findings indicated had been under-appreciated or mistakenly considered a rarity. So, in 2019, his team proceeded to isolate 13 new viruses, including one frozen under a lake more than 48,500 years ago, from seven different ancient Siberian permafrost samples - evidence to their ubiquity. Publishing the findings in a 2022 study, he emphasized that a viral infection from an unknown, ancient pathogen in humans, animals or plants could have potentially "disastrous" effects. "50,000 years back in time takes us to when Neanderthal disappeared from the region," he says. "If Neanderthals died of an unknown viral disease and this virus resurfaces, it could be a danger to us."

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