US Prepares For Bird Flu Pandemic With $176 Million Moderna Vaccine Deal

An anonymous reader quotes a report from Ars Technica: The US government will pay Moderna $176 million to develop an mRNA vaccine against a pandemic influenza -- an award given as the highly pathogenic bird flu virus H5N1 continues to spread widely among US dairy cattle. The funding flows through BARDA, the Biomedical Advanced Research and Development Authority, as part of a new Rapid Response Partnership Vehicle (RRPV) Consortium. The program is intended to set up partnerships with industry to help the country better prepare for pandemic threats and develop medical countermeasures, the Department of Health and Human Services said in a press announcement Tuesday. In its own announcement on Tuesday, Moderna noted that it began a Phase 1/2 trial of a pandemic influenza virus vaccine last year, which included versions targeting H5 and H7 varieties of bird flu viruses. The company said it expects to release the results of that trial this year and that those results will direct the design of a Phase 3 trial, anticipated to begin in 2025. The funding deal will support late-stage development of a "pre-pandemic vaccine against H5 influenza virus," Moderna said. But, the deal also includes options for additional vaccine development in case other public health threats arise. US health officials have said previously that they were in talks with Moderna and Pfizer about the development of a pandemic bird flu vaccine. The future vaccine will be in addition to standard protein-based bird flu vaccines that are already developed. In recent weeks, the health department has said it is working to manufacture 4.8 million vials of H5 influenza vaccine in the coming months. The plans come three months into the H5N1 dairy outbreak, which is very far from the initial hopes of containment. [...] The more the virus expands its footprint across US dairy farms, adapts to its newfound mammalian host, and comes in contact with humans, the more and more chances it has to leap to humans and gain the ability to spread among us. "The award made today is part of our longstanding commitment to strengthen our preparedness for pandemic influenza," said Dawn O'Connell, assistant secretary for Preparedness and Response. "Adding this technology to our pandemic flu toolkit enhances our ability to be nimble and quick against the circulating strains and their potential variants." In a separate article, Ars Technica reports on a small study in Texas that suggests human cases are going undetected on dairy farms where the H5N1 virus has spread in cows.

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