Common Low-Calorie Sweetener May Be Riskier For the Heart Than Sugar, Study Suggests

Another study is raising concern about the safety of the widely used sugar alcohol sweetener erythritol, a low-calorie sugar substitute found in "keto-friendly" foods, baked goods and candies. From a report: Researchers from the Cleveland Clinic compared erythritol to typical sugar and found only erythritol caused worrisome cardiovascular effects. Although the study was small, it's the first head-to-head look at people's blood levels after they consume products with erythritol or sugar (glucose). "We compared the results, and glucose caused none of the problems," said Dr. Stanley Hazen, a cardiologist at the Cleveland Clinic and the lead author of the study, published Thursday morning in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. Erythritol is one ingredient on a growing list of nonsugar sweeteners found in low-calorie and sugar-free foods. Erythritol and xylitol are sugar alcohols that are sweet like sugar but with far fewer calories. Erythritol is often mixed with another sweetener, stevia, and xylitol is often found in gum, mouthwash and toothpaste. Earlier studies from Hazen's lab -- one published last year and the other in June -- found potential links between the sugar alcohols and an increased risk of heart attacks and strokes. The research suggested both sugar alcohols might make blood platelets stickier and therefore more susceptible to clotting and blocking veins or arteries, in turn contributing to heart attacks and strokes. For the new research, Hazen's team analyzed the heart effects of erythritol and regular sugar -- in this case, simple glucose -- by enrolling two groups of healthy middle-aged male and female volunteers: 10 who consumed the erythritol and 10 who consumed sugar.

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