First Brain-Wide Map of Decision-Making Charted In Mice

In a landmark collaboration across 22 labs, neuroscientists have created the first brain-wide map of decision-making in mice, tracking over 620,000 neurons across nearly 280 brain regions. They found that decision-making is distributed much more broadly than previously thought, involving not just "cognitive" centers but also regions linked to movement. From a report: The task was deceptively simple task. Mice sat in front of a screen that intermittently displayed a black-and-white striped circle for a brief amount of time on either the left or right side. A mouse could earn a sip of sugar water if they quickly moved the circle toward the center of the screen by operating a tiny steering wheel in the same direction, often doing so within one second. On some trials, the circle was faint, requiring the animal to rely on past experience to make a guess, which allowed researchers to study how expectations influence future decisions. While the mice performed the task, researchers recorded brain activity using high-density electrodes that allowed them to monitor hundreds of neurons across many regions simultaneously. The work was divided across the participating labs, so that each lab mapped a particular region of the mouse brain. The pooled dataset covers 620,000 neurons recorded from 139 mice in 12 labs, encompassing nearly the entire brain. The resulting map revealed that decision-making activity is distributed across the brain, including in areas traditionally associated with movement rather than cognition. The findings have been published in two papers in the journal Nature.

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