NFL Week 2 preview! Can Caleb beat Lions? Hoss fight in Houston, Super Bowl rematch

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Nate Tice & Charles McDonald dive into Week 2 of NFL action, covering what to watch, their hoss fight of the week, bold predictions and more. After discussing the fallout of Brock Purdy's toe injury, Nate & Charles kick things off by getting Lost in the Sauce on their three deep dives of the week, including the Seattle Seahawks heading to Pittsburgh, a Super Bowl rematch with the Philadelphia Eagles taking on the Kansas City Chiefs and a hoss fight in Houston with the Tampa Bay Buccaneers taking on the Houston Texans.

Later, Nate & Charles give their Big Dog of the Week (can Caleb Williams defeat the Detroit Lions?) and their Hail Mary predictions involving the Jacksonville Jaguars & Minnesota Vikings.

(1:50) - Can the San Francisco 49ers survive without Brock Purdy?

(6:05) - Seahawks @ Steelers preview

(21:05) - Eagles @ Chiefs preview

(36:10) - Buccaneers @ Texans preview

(49:00) - Big Dog of the Week: Chicago Bears

(1:00:55) - Hail Mary predictions

CHICAGO, ILLINOIS - SEPTEMBER 8: Caleb Williams #18 of the Chicago Bears reacts after scoring a touchdown during the first half of an NFL football game against the Minnesota Vikings at Solider Field on September 8, 2025 in Chicago, Illinois. (Photo by Todd Rosenberg/Getty Images)(Photo by Todd Rosenberg/Getty Images)

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