Michigan State vs. Toledo Prediction, Odds, Picks for College Football Week 1

The Michigan State Spartans will kick off their 2026 college football season against the Toledo Rockets at Spartan Stadium on Friday in a Week 1 matchup on FS1. A new era begins for both programs, with new head coaches leading the way. The Spartans hired Pat Fitzgerald to turn around a program that reached the four-team College Football Playoff in 2015 but hasn't posted a winning season since 2021. With a revamped roster and plenty of new faces, Fitzgerald will get his first look at what this new-look Michigan State team is capable of. Toledo also enters a new era under Mike Jacobs after Jason Candle left to become the head coach at UConn. Jacobs has won everywhere he's been, compiling a 94-23 career record as a head coach. Now, he'll bring that success to the MAC and look to keep the Rockets among the conference's top programs. However, with a new coaching staff and a heavily revamped roster, Toledo could experience some early growing pains against a Big Ten opponent. Let's take a look at the odds for Michigan State vs. Toledo at FanDuel Sportsbook as of Sept. 4. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Moneyline Spread Over/Under From FOX Sports Research How to Watch Michigan State vs. Toledo