Lamar Jackson ruled out of Bills-Ravens game with thumb injury sustained on Baltimore's first offensive play

Ravens quarterback Lamar Jackson left Sunday's game against the Buffalo Bills with a right thumb injury on Baltimore's first offensive play from scrimmage.

The Ravens ruled him out for the game before the conclusion of the first quarter.

Jackson took contact on his hand after a pass and was in immediate pain. He left the field and walked straight to the locker room. Backup Tyler Huntley took his place at quarterback.

The Ravens announced that he was questionable to return with a thumb injury before ruling him out. The injury is to the thumb on his throwing hand.

Lamar Jackson heads to the locker room after his first pass attempt with an apparent hand injury. pic.twitter.com/JVUQYjJV8H

- NFL on CBS (@NFLonCBS) November 1, 2026

Jackson, a two-time NFL MVP, was playing in his first game since sustaining a high-ankle sprain in Week 4 that caused him to miss three games. He returned to the 4-3 Ravens in time for the critical AFC showdown against Josh Allen and the Bills, but now he's out against the Bills and potentially for longer

The injury is another difficult blow for Jackson and Ravens team seeking to compete for a Super Bowl championship. Jackson is one of the game's best players when healthy, but injuries have derailed his last two seasons.

This story will be updated.