Critical step in cellular repair of damaged DNA identified which could be big for reversing aging and human trials will start within six months
by noreply@blogger.com (brian wang) from NextBigFuture.com on (#2H06V)
UNSW researchers have identified a critical step in the molecular process that allows cells to repair damaged DNA - and it could mean big things for the future of anti-ageing drugs, childhood cancer survivors and even astronauts. It could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.
Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.
While our cells have an innate capability to repair DNA damage a' which happens every time we go out into the sun, for example - their ability to do this declines as we age.
The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair.
Treating mice with a NAD+ precursor, or "booster," called NMN improved their cells' ability to repair DNA damage caused by radiation exposure or old age.
"The cells of the old mice were indistinguishable from the young mice, after just one week of treatment," said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.
Human trials of NMN therapy will begin within six months.
"This is the closest we are to a safe and effective anti-aging drug that's perhaps only three to five years away from being on the market if the trials go well," says Sinclair, who maintains a lab at UNSW in Sydney.
Science - A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
An anti-ageing pill could be on the horizon
For the past four years, Professor Sinclair and Dr Wu have been working on making NMN into a drug substance with their companies MetroBiotech NSW and MetroBiotech International.
The human trials will begin this year at Brigham and Women's Hospital, in Boston.
The findings on NAD+ and NMN add momentum to the exciting work the UNSW Laboratory for Ageing Research has done over the past four years.
They've been looking at the interplay of a number of proteins and molecules and their roles in the ageing process.
They had already established that NAD+ could be useful for treating various diseases of ageing, female infertility and also treating side effects of chemotherapy.
In 2003, Professor Sinclair made a link between the anti-ageing enzyme SIRT1 and resveratrol, a naturally occurring molecule found in tiny quantities in red wine.
"While resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity," he says.
Read more
Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.
While our cells have an innate capability to repair DNA damage a' which happens every time we go out into the sun, for example - their ability to do this declines as we age.
The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair.
Treating mice with a NAD+ precursor, or "booster," called NMN improved their cells' ability to repair DNA damage caused by radiation exposure or old age.
"The cells of the old mice were indistinguishable from the young mice, after just one week of treatment," said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.
Human trials of NMN therapy will begin within six months.
"This is the closest we are to a safe and effective anti-aging drug that's perhaps only three to five years away from being on the market if the trials go well," says Sinclair, who maintains a lab at UNSW in Sydney.
Science - A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
An anti-ageing pill could be on the horizon
For the past four years, Professor Sinclair and Dr Wu have been working on making NMN into a drug substance with their companies MetroBiotech NSW and MetroBiotech International.
The human trials will begin this year at Brigham and Women's Hospital, in Boston.
The findings on NAD+ and NMN add momentum to the exciting work the UNSW Laboratory for Ageing Research has done over the past four years.
They've been looking at the interplay of a number of proteins and molecules and their roles in the ageing process.
They had already established that NAD+ could be useful for treating various diseases of ageing, female infertility and also treating side effects of chemotherapy.
In 2003, Professor Sinclair made a link between the anti-ageing enzyme SIRT1 and resveratrol, a naturally occurring molecule found in tiny quantities in red wine.
"While resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity," he says.
Read more