Root Bacterium to Fight Alzheimer's: Rhizolutin Dissociates Beta and Tau Aggregates
upstart writes in with an IRC submission for Runaway1956:
Root bacterium to fight Alzheimer's: Rhizolutin dissociates beta and tau aggregates:
A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer's. Rhizolutin, a novel class of compounds with a tricyclic framework, significantly dissociates the protein aggregates associated with Alzheimer's disease both in vivo and in vitro, as reported by scientists in the journal Angewandte Chemie
The area around the roots of plants is a complex ecosystem with numerous interactions between plants and diverse microorganisms. The so-called rhizosphere has been neglected in the search for new drugs, though it has much to offer. A team working with YoungSoo Kim (Yonsei University, Incheon, South Korea) and Dong-Chan Oh (Seoul National University, South Korea) has now identified a natural substance called rhizolutin that may provide a basis for novel Alzheimer's disease treatments. Rhizolutin is produced by a Streptomyces strain that grows in the root zone of ginseng plants. Ginseng is an Asian plant used in traditional medicine, where it is said to be a tonic.
Journal Reference:
Yun Kwon, Jisu Shin, Kwangho Nam, et al. Rhizolutin, a Novel 7/10/6Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease, Angewandte Chemie International Edition (DOI: 10.1002/anie.202009294)
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