Novel Molecules Discovered to Combat Asthma and COVID-Related Lung Diseases
upstart writes in with an IRC submission for Bytram:
Novel Molecules Discovered to Combat Asthma and COVID-Related Lung Diseases:
A study designed to study how the immune system impacts gut bacteria - has led to the extraordinary discovery of two molecules that can not only provide profound protection in experimental models of asthma but can also substantially reduce the severity of an attack.
Neither of these molecules, one of which is already commercially available as a dietary supplement, were previously known to have an effect on asthma - and they also appear, from animal studies, to have a role in treating the respiratory illness that is prevalent, and often fatal, in people with serious COVID-19.
The researchers aim to test one of the molecules in a clinical trial in 2021 in asthmatics.
As further evidence that these two molecules could potentially protect against asthma the Monash University researchers found, through studying the literature, that these metabolites are present in higher amounts in two studies of children without asthma compared to those with the disease, according to Professor Benjamin Marsland from the Monash University Central Clinical School, whose paper is published today in Nature Immunology.
Journal Reference:
Tomasz P. Wypych, Celine Pattaroni, Olaf Perdijk, et al. Microbial metabolism of l -tyrosine protects against allergic airway inflammation, Nature Immunology (DOI: 10.1038/s41590-020-00856-3)
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