Scientists Grew Stem Cell 'Mini Brains'. Then, the Brains Sort-of Developed Eyes
upstart writes:
Scientists Grew Stem Cell 'Mini Brains'. Then, The Brains Sort-of Developed Eyes:
Mini brains grown in a lab from stem cells have spontaneously developed rudimentary eye structures, scientists report in a fascinating new paper.
On tiny, human-derived brain organoids grown in dishes, two bilaterally symmetrical optic cups were seen to grow, mirroring the development of eye structures in human embryos. This incredible result will help us to better understand the process of eye differentiation and development, as well as eye diseases.
"Our work highlights the remarkable ability of brain organoids to generate primitive sensory structures that are light sensitive and harbor cell types similar to those found in the body," said neuroscientist Jay Gopalakrishnan of University Hospital Dusseldorf in Germany.
"These organoids can help to study brain-eye interactions during embryo development, model congenital retinal disorders, and generate patient-specific retinal cell types for personalized drug testing and transplantation therapies."
Brain organoids are not true brains, as you might be thinking of them. They are small, three-dimensional structures grown from induced pluripotent stem cells - cells harvested from adult humans and reverse engineered into stem cells, that have the potential to grow into many different types of tissue.
Journal Reference:
Elke Gabriel, Walid Albanna, Giovanni Pasquini, Anand Ramani, Natasa Josipovic, Aruljothi Mariappan, Friedrich Schinzel, Celeste M. Karch, Guobin Bao, Marco Gottardo, Ata Alp Suren, Jurgen Hescheler, Kerstin Nagel-Wolfrum, Veronica Persico, Silvio O. Rizzoli, Janine Altmuller, Maria Giovanna Riparbelli, Giuliano Callaini, Olivier Goureau, Argyris Papantonis, Volker Busskamp, Toni Schneider, Jay Gopalakrishnan. Human brain organoids assemble functionally integrated bilateral optic vesicles. Cell Stem Cell, 2021; DOI: 10.1016/j.stem.2021.07.010
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