Scientists Can Tell Healthy And Cancerous Cells Apart By How They Move

Arthur T Knackerbracket has processed the following story:

by Tokyo Metropolitan University

Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma cells and healthy fibroblasts on a dish and found that tracking and analysis of their paths can be used to differentiate them with up to 94% accuracy.

Beyond diagnosis, their technique may also shed light on cell motility-related functions, like tissue healing. The paper is published in the journal PLOS ONE.

While scientists and medical experts have been looking at cells under the microscope for many centuries, most studies and diagnoses focus on their shape, what they contain, and where different parts are located inside. But cells are dynamic, changing over time, and are known to be able to move.

By accurately tracking and analyzing their motion, we may be able to differentiate cells which have functions relying on cell migration. An important example is cancer metastasis, where the motility of cancerous cells allows them to spread.

However, this is easier said than done. For one, studying a small subset of cells can give biased results. Any accurate diagnostic technique would rely on automated, high-throughput tracking of a significant number of cells.

Many methods then turn to fluorescent labeling, which makes cells much easier to see under the microscope. But this labeling procedure can itself affect their properties. The ultimate goal is an automated method which uses label-free conventional microscopy to characterize cell motility and show whether cells are healthy or not.

Now, a team of researchers from Tokyo Metropolitan University led by Professor Hiromi Miyoshi have come up with a way of tracking cells using phase-contrast microscopy, one of the most common ways of observing cells.

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