Christian McCaffey limited at 49ers practice with calf injury on heels of season riddled with injuries

SANTA CLARA, CA - AUGUST 05: San Francisco 49ers running back Christian McCaffrey (23) looks on during San Francisco 49ers Training Camp on August 5, 2025 at the SAP Performance Facility in Santa Clara, CA. (Photo by Matthew Huang/Icon Sportswire via Getty Images)Icon Sportswire via Getty Images

This is concerning news.

All-Pro 49ers running back Christian McCaffrey showed up as limited on San Francisco's practice report Thursday with a calf injury. He was previously a full participant at practice as the 49ers ramped up for the 2025 season. Details about the injury were not initially clear.

Here is today's 49ers injury report in which RB Christian McCaffey was added with a calf injury one day after he fully participated in practice: pic.twitter.com/ohjq3sALPv

- Adam Schefter (@AdamSchefter) September 5, 2025

News of McCaffrey's injury arrives three days before the 49ers are scheduled to open their season Sunday against the Seattle Seahawks.

McCaffrey was limited to just four games last season while dealing with calf and Achilles injuries.

When healthy, McCaffrey is one of the NFL's most potent offensive weapons and an elite dual-threat weapon out of the backfield. Six plays later, Javonte Williams ran for a one-yard touchdown to give the Cowboys a 7-0 lead.

This story will be updated.