Big pharma firms have paused nearly £2bn in UK investments this year

Government's plans in disarray before Trump talks as MSD, Eli Lilly and AstraZeneca moves prompt job fears

Big pharmaceutical companies have ditched or paused nearly 2bn in planned UK investments so far this year, causing suffering" to patients, as ministers gear up for discussions with Donald Trump amid a row over drug pricing.

The government's plan for the life science sector, a key pillar of the economy, has been thrown into disarray, after US drugmaker MSD's shock announcement last Wednesday that it would scrap its 1bn London research centre. Two days later, AstraZeneca decided to halt a planned 200m expansion of its research facilities in Cambridge.