He Made Beer That's Also a Vaccine. Now Controversy is Brewing

hubie writes:

A scientist's unconventional project illustrates many challenges in developing new vaccines:

Chris Buck stands barefoot in his kitchen holding a glass bottle of unfiltered Lithuanian farmhouse ale. He swirls the bottle gently to stir up a fingerbreadth blanket of yeast and pours the turbulent beer into a glass mug.

Buck raises the mug and sips. "Cloudy beer. Delightful!"

He has just consumed what may be the world's first vaccine delivered in a beer. It could be the first small sip toward making vaccines more palatable and accessible to people around the world. Or it could fuel concerns about the safety and effectiveness of vaccines. Or the idea may go nowhere. No matter the outcome, the story of Buck's unconventional approach illustrates the legal, ethical, moral, scientific and social challenges involved in developing potentially life-saving vaccines.

Buck isn't just a home brewer dabbling in drug-making. He is a virologist at the National Cancer Institute in Bethesda, Md., where he studies polyomaviruses, which have been linked to various cancers and to serious health problems for people with weakened immune systems. He discovered four of the 13 polyomaviruses known to infect humans.

The vaccine beer experiment grew out of research Buck and colleagues have been doing to develop a traditional vaccine against polyomavirus. But Buck's experimental sips of vaccine beer are unsanctioned by his employer. A research ethics committee at the National Institutes of Health told Buck he couldn't experiment on himself by drinking the beer.

Buck says the committee has the right to determine what he can and can't do at work but can't govern what he does in his private life. So today he is Chef Gusteau, the founder and sole employee of Gusteau Research Corporation, a nonprofit organization Buck established so he could make and drink his vaccine beer as a private citizen. His company's name was inspired by the chef in the film Ratatouille, Auguste Gusteau, whose motto is "Anyone can cook."

Buck's body made antibodies against several types of the virus after drinking the beer and he suffered no ill effects, he and his brother Andrew Buck reported December 17 at the data sharing platform Zenodo.org, along with colleagues from NIH and Vilnius University in Lithuania. Andrew and other family members have also consumed the beer with no ill effects, he says. The Buck brothers posted a method for making vaccine beer December 17 at Zenodo.org. Chris Buck announced both publications in his blog Viruses Must Die on the online publishing platform Substack, but neither has been peer-reviewed by other scientists.

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