One immune cell type appears to attack any type of cancer

Enlarge / False-colored image of an electron micrograph of a T cell. (credit: NIAID)

While cancerous cells look a lot like normal human cells, they're still different enough that the immune system regularly attacks them. Obviously, this attack sometimes bogs down, allowing cancer to thrive and spread. Figuring out how to get the immune system back on track has been a major focus of research, and success in the area has been honored with a Nobel Prize.

Despite these successes, many patients aren't helped by the newer immune-focused therapies, raising questions of what else we still need to figure out to help cancer patients. A new paper highlights something we may have missed: a class of immune cells that appears to be primed specifically to attack cancer. But the finding raises questions about what it is on cancer cells that the immune cells are recognizing and why they fail to keep cancer in check.

Finding cancer killers

The start of this work was pretty simple: a large international team of researchers grew a mix of immune cells called "T cells" in the presence of cancerous cells and looked for cells that grew rapidly. This rapid growth is typically a sign that the immune cells have been activated by something they recognize-in this case, the cancer. They identified one particular lineage of T cells that grew well and named it MC.7.G5, confirming yet again that most scientists don't belong in the creative industries.

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