Potential Early Biomarker To Track Development Of Non-Alcoholic Fatty Liver Disease
Arthur T Knackerbracket has found the following story:
Fatty liver disease not associated with alcohol consumption, which is called Nonalcoholic Fatty Liver Disease or NAFLD, affects more than one billion people worldwide. Even in children the numbers are overwhelming, with up to 80 percent of pediatric patients who are considered obese affected worldwide. People with NAFLD can progress to a severe form known as nonalcoholic steatohepatitis (NASH), which puts patients at higher risk for cirrhosis or liver cancer.
With no definitive treatment options or early detection methods yet discovered, researchers have been hard at work to identify early biomarkers of this disease. "This becomes also especially important in the context of diabetes because individuals with Type 2 diabetes are much more susceptible to this disease," says Rohit N. Kulkarni, MD, PhD, Section Head, Senior Investigator, Islet Cell and Regenerative Biology, Joslin Diabetes Center, and Professor of Medicine, Harvard Medical School.
But recent research from Dr. Kulkarni's lab at Joslin has uncovered a biomarker in humans tied to the development of NAFLD that might help doctors detect early stages of the disease. The researchers also determined that this biomarker, a protein known as "neuronal regeneration related protein" (or NREP), plays a significant role in the regulation of a pathway that is currently being reviewed in clinical trials as a treatment option for the disease. The study was published today in Journal of Clinical Investigation.
"We identified NREP as a new biomarker for NAFLD that is involved in the regulation of liver fat metabolism and in a process called fibrosis that occurs during the progression of the fatty liver disease that may lead to cirrhosis and liver cancer" says Dario F. De Jesus, MSc, PhD, a postdoctoral research fellow in the Kulkarni Lab at Joslin and lead author on the study.
Journal Reference:
Dario F. De Jesus, Kazuki Orime, Dorota Kaminska, Tomohiko Kimura, Giorgio Basile, Chih-Hao Wang, Larissa Haertle, Renzo Riemens, Natalie K. Brown, Jiang Hu, Ville Minnisti, Ami(C)lia M. Silva, Ercument Dirice, Yu-Hua Tseng, Thomas Haaf, Jussi Pihlajamiki, Rohit N. Kulkarni. Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. Journal of Clinical Investigation, 2020; DOI: 10.1172/JCI127502
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