Strength and Immune System Improved in Old Mice Using Transfer of Immune Cells
takyon writes:
Age-related impairments reversed in animal model (SD)
Frailty and immune decline are two main features of old age. Researchers from the University of Bern and the University Hospital Bern now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.
[...] The team around Dr. Noti and Dr. Eggel could demonstrated that a certain kind of immune cells, known as eosinophils, which are predominantly found in the blood circulation, are also present in belly fat of both humans and mice. Although classically known to provide protection from parasite infection and to promote allergic airway disease, eosinophils located in belly fat are responsible to maintain local immune homeostasis. With increasing age the frequency of eosinophils in belly fat declines, while the number of pro-inflammatory macrophages increases. Owing to this immune cell dysbalance, belly fat turns into a source of pro-inflammatory mediators accumulating systemically in old age.
In a next step, the researchers investigated the possibility to reverse age-related impairments by restoring the immune cell balance in visceral adipose tissue. "In different experimental approaches, we were able to show that transfers of eosinophils from young mice into aged recipients resolved not only local but also systemic low-grade inflammation", says Dr. Eggel. "In these experiments, we observed that transferred eosinophils were selectively homing into adipose tissue", adds Dr. Noti. This approach had a rejuvenating effect on the aged organism. As a consequence, aged animals showed significant improvements in physical fitness as assessed by endurance and grip strength tests. Moreover, the therapy had a rejuvenating effect on the immune system manifesting in improved vaccination responses of aged mice.
They managed to work COVID-19 into the press release.
Journal References:
Daniel Brigger, Carsten Riether, Robin van Brummelen, et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age, Nature Metabolism (DOI: 10.1038/s42255-020-0228-3)
Chih-Hao Lee. Young eosinophils rejuvenate ageing adipose tissues, Nature Metabolism (DOI: 10.1038/s42255-020-0230-9)
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