Ebola Vaccine Regimen Generates Strong Immune Response in Children and Adults in a Clinical Trial
upstart writes:
Results support the use of Johnson & Johnson's vaccine regimen for Ebola virus disease prevention
Johnson & Johnson's two-dose Ebola vaccine regimen is safe, well tolerated and produces a strong immune response in people over the age of one, according to two new papers published in The Lancet Infectious Diseases.
The EBOVAC-Salone study provides important further evidence for the potential of the regimen using the Ad26.ZEBOV and MVA-BN-Filo vaccines to be used as a protective measure against Ebola virus disease for both children and adults.
Conducted in Sierra Leone, the study is the first to assess the safety and tolerability of this vaccine regimen in a region affected by the 2014-2016 West African Ebola outbreak, which was the worst on record. It is also the first study reporting the evaluation of this vaccine regimen in children.
[...] The authors found that the vaccine regimen was well tolerated and induced antibody responses to Zaire ebolavirus 21 days after the second dose in 98% of participants, with the immune responses persisting in adults for at least two years.
During the 2014-16 outbreak of Ebola in West Africa, 28,652 cases and 11,325 deaths from Ebola were reported. Approximately 20% of cases were in children under 15 years, and children younger than five years are at a higher risk of death than adults.
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