AI Helps Show how the Brain’s Fluids Flow
fliptop writes:
A new artificial intelligence-based technique for measuring fluid flow around the brain's blood vessels could have big implications for developing treatments for diseases such as Alzheimer's:
The perivascular spaces that surround cerebral blood vessels transport water-like fluids around the brain and help sweep away waste. Alterations in the fluid flow are linked to neurological conditions, including Alzheimer's, small vessel disease, strokes, and traumatic brain injuries but are difficult to measure in vivo.
A multidisciplinary team of mechanical engineers, neuroscientists, and computer scientists led by University of Rochester Associate Professor Douglas Kelley developed novel AI velocimetry measurements to accurately calculate brain fluid flow. The results are outlined in a study published by Proceedings of the National Academy of Sciences.
[...] The work builds upon years of experiments led by study coauthor Maiken Nedergaard, the codirector of Rochester's Center for Translational Neuromedicine. The group has previously been able to conduct two-dimensional studies on the fluid flow in perivascular spaces by injecting tiny particles into the fluid and measuring their position and velocity over time. But scientists needed more complex measurements to understand the full intricacy of the system-and exploring such a vital, fluid system is a challenge.
Journal Reference: Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows - https://doi.org/10.1073/pnas.2217744120
Originally spotted on The Eponymous Pickle.
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