Work Begins to Create Artificial Human DNA From Scratch

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https://www.bbc.com/news/articles/c6256wpn97ro

Work has begun on a controversial project to create the building blocks of human life from scratch, in what is believed to be a world first.

The research has been taboo until now because of concerns it could lead to designer babies or unforeseen changes for future generations.

But now the World's largest medical charity, the Wellcome Trust, has given an initial 10m to start the project and says it has the potential to do more good than harm by accelerating treatments for many incurable diseases.

Dr Julian Sale, of the MRC Laboratory of Molecular Biology in Cambridge, who is part of the project, told BBC News the research was the next giant leap in biology.

"The sky is the limit. We are looking at therapies that will improve people's lives as they age, that will lead to healthier aging with less disease as they get older.

"We are looking to use this approach to generate disease-resistant cells we can use to repopulate damaged organs, for example in the liver and the heart, even the immune system," he said.

But critics fear the research opens the way for unscrupulous researchers seeking to create enhanced or modified humans.

Dr Pat Thomas, director of the campaign group Beyond GM, said: "We like to think that all scientists are there to do good, but the science can be repurposed to do harm and for warfare".

[...] The Human Genome Project enabled scientists to read all human genes like a bar code. The new work that is getting under way, called the Synthetic Human Genome Project, potentially takes this a giant leap forward - it will allow researchers not just to read a molecule of DNA, but to create parts of it - maybe one day all of it - molecule by molecule from scratch.

[...] "Building DNA from scratch allows us to test out how DNA really works and test out new theories, because currently we can only really do that by tweaking DNA in DNA that already exists in living systems".

The project's work will be confined to test tubes and dishes and there will be no attempt to create synthetic life. But the technology will give researchers unprecedented control over human living systems.

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