Story 2014-02-26

The hypothetical rescue of the Columbia - and its effects on NASA's future missions

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in space on (#3EY)
story imageArs Technica writer Lee Hutchinson , who worked for NASA during the Columbia incident , writes about the 2003 destruction of the shuttle Columbia, and the questions asked afterwards. Could the disaster have been anticipated? If so, could a rescue have been performed before the shuttle's incredibly destructive re-entry? The answers to those questions hatched an incredible plan - and changed the way NASA handles shuttle missions to this day. It's worth a read not only for the historical perspective, but also for the account of practical project planning and the immense scope of such an endeavor. He calls it the untold story of the rescue mission that could have been NASA's finest hour .

Zohydro, the Next OxyContin?

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in science on (#3EX)
story imagePharmaceutical company Zogenix has received US FDA approval to launch a new hydrocodone-based analgesic in March. The drug is intended only for chronic pain, not as an short term or as-needed analgesic. CNN is reporting a coalition of groups are lobbying for the FDA to revoke their approval before the medicine is even available.

The concerns echoed by all groups are broadly about the drug's potency and abuse potential. They say they fear that Zohydro -- especially at higher doses -- will amplify already-rising overdose numbers.

"You're talking about a drug that's somewhere in the neighborhood of five times more potent than what we're dealing with now," said Dr. Stephen Anderson, a Washington emergency room physician who is not part of the most recent petition to the FDA about the drug. "I'm five times more concerned, solely based on potency."

A number of other news outlets are hyping the potency of Zohydro, going so far as calling the drug ten times more powerful than a 5mg Vicodan. A fairer comparison may be to OxyCodone, since they have similar opioid levels. Zohydro ER will be available in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, and 50 mg strengths.

Chemistry Pipedotters can find the structural formula for hydrocodone bitartrate on RxList.

Should the FDA allow such a potent medication on the market? Or would moving opioid analgesics to Schedule II mitigate the potential for abuse?

Time Magazine thinks iOS won the app war

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in mobile on (#3EW)
Over at Time Magazine, Harry McCracken has taken a closer look at the differences between iOS and Android and concluded that for the most part, they're equivalent in form and function. But not in one remaining area: app availability. Here, McCracken complains, Android is constantly playing catch up and iOS apps too frequently arrive sooner and in better form.