Story 2015-11-28

Genetically engineered algae kills 90% of cancer cells without harming healthy cells

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in science on (#VZJ3)
Algae has been genetically engineered to kill cancer cells without harming healthy cells. The algae nanoparticles, created by scientists in Australia, were found to kill 90% of cancer cells in cultured human cells. The algae was also successful at killing cancer in mice with tumours.

"By genetically engineering diatom algae - tiny, unicellular, photosynthesising algae with a skeleton made of nanoporous silica, we are able to produce an antibody-binding protein on the surface of their shells. Anti-cancer chemotherapeutic drugs are often toxic to normal tissues. [...]To minimise the off-target toxicity, the drugs can be hidden inside the antibody-coated nanoparticles. The antibody binds only to molecules found on cancer cells, thus delivering the toxic drug specifically to the target cells."

Understanding the US government's dismal IT project track record

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in legal on (#VZGD)
A lot of times the systems are politically mandated in the sense that you have somebody on the Hill or Congress who will mandate a system and they'll mandate a particular period of time and they'll mandate the amount of money to spend and they have absolutely no idea what they're talking about. So what happens is, if you're there as a government person, you're trying to translate some political wish into something that's topical and it's not very easy," Bob Charette says. Another problem is that there isn't much accountability when it comes to projects that fail.

One infamous example of government failure is the system that handles disability claims for Social Security. In the early 2000s, Congress spent money to try and reduce the massive backlog in claim processing that had built up. The backlog, however, only grew. Then in 2007, they spent more money - an estimated $381 million - to try and integrate 54 different IT systems that the Social Security Administration uses to process claims in the state. In 2011 they spent another $200 million on the project. "After six years ... they found out that they really didn't have anything." The backlog for Social Security claims continues to grow, and the latest attempt to fix the problem failed again this past summer. "By any stretch of imagination, it's scandalous."