If you spend a good portion of your waking hours behind a desk, simply slapping an ergonomic mouse and keyboard on your desk won't solve the real problem, which is sitting still for too long. But after you've peppered in a few walks and added some stretches for good measure, your workstation ergonomics is the next thing to consider. Hunching, twisting and contorting are all likely to lead to discomfort in the long run.